Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury.

ABSTRACT: Cardiomyocyte proliferation and dedifferentiation have fueled the field of regenerative cardiology in recent years, whereas the reverse process of redifferentiation remains largely unexplored. Redifferentiation is characterized by the restoration of function lost during dedifferentiation. Previously, we showed that ERBB2-mediated heart regeneration has these two distinct phases: transient dedifferentiation and redifferentiation. Here we survey the temporal transcriptomic and proteomic landscape of dedifferentiation-redifferentiation in adult mouse hearts and reveal that well-characterized dedifferentiation features largely return to normal, although elements of residual dedifferentiation remain, even after the contractile function is restored. These hearts appear rejuvenated and show robus

SUBMITTER: Shakked A 

PROVIDER: S-EPMC10653068 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature