Triboelectric Nanogenerator-Coated Blade Spray Mass Spectrometry for Volume-Limited Drug Analysis.

ABSTRACT: The demand for analytical tools for the analysis of low-concentration volume-limited samples has driven researchers to explore new analytical approaches. Mass spectrometry excels at trace analysis due to its high sensitivity and specificity, whereas ambient methods simplify, or completely eliminate sample preparation. Herein, we report a triboelectric nanogenerator-coated blade spray ambient mass spectrometry (TENG-CBS MS) method for the extraction, elution, and ionization of volume-limited, low-concentration small molecule drug samples with minimum sample preparation. Using a TENG device as the CBS power supply, we show it is possible to extract and analyze drug samples in a pulsed fashion at sub-nanogram to picogram levels with good stability and reproducibility. A wide range of analytes

SUBMITTER: Ma X 

PROVIDER: S-EPMC10653212 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature