Immunogenicity and reactogenicity of yellow fever vaccine in people with HIV.

ABSTRACT:

Objective

To evaluate immunogenicity and reactogenicity of yellow fever (YF) vaccine in people with HIV (PWH) compared to HIV-uninfected controls.

Design

In this longitudinal interventional trial (NCT03132311), PWH with CD4 + cell count ≥200 cells/μl and controls, aged 18-59, without a previous history of YF vaccination received a single standard dose of YF vaccine (17DD) and were followed at Days 5, 30 and Year 1.

Methods

YF-neutralization titers were measured at Days 0, 30 and Year 1 and geometric mean titers (GMT) were calculated. Adverse events (AE) and YF virus detection were measured at Days 5 and 30. Linear regression evaluated factors associated with YF-neutralization titers.

Results

Two hundred and eighteen PWH and 82 controls were included. At baselin

SUBMITTER: Motta E 

PROVIDER: S-EPMC10653289 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature