Virological and immunological correlates of HIV posttreatment control after temporal antiretroviral therapy during acute HIV infection.

ABSTRACT:

Objective

People with HIV rarely control viral replication after cessation of antiretroviral therapy (ART). We present a person with HIV with extraordinary posttreatment control (PTC) for over 23 years after temporary ART during acute HIV infection (AHI) leading to a new insight in factors contributing to PTC.

Design/methods

Viral reservoir was determined by HIV qPCR, Intact Proviral DNA Assay, and quantitative viral outgrowth assay. Viral replication kinetics were determined in autologous and donor PBMC. IgG levels directed against HIV envelope and neutralizing antibodies were measured. Immune phenotyping of T cells and HIV-specific T-cell responses were analyzed by flow cytometry.

Results

The case presented with AHI and a plasma viral load of 2.7 million copies/ml.

SUBMITTER: van Paassen PM 

PROVIDER: S-EPMC10653294 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature