Immunogenicity of tetanus, diphtheria and acellular pertussis vaccination among pregnant women living with and without HIV.

ABSTRACT:

Objective

Vaccination during pregnancy with tetanus-diphtheria-acellular pertussis (Tdap) vaccine is recommended to protect the young infants against pertussis. There is a paucity of data on immune responses to Tdap in pregnant women with HIV (PWWH), and its impact on the protection of their infants has not been described.

Methods

In an open label phase IV clinical trial in South Africa, we evaluated the immunogenicity and safety of Tdap in PWWH compared with HIV-uninfected women. Antigen-specific immunoglobulin G (IgG) to pertussis toxoid, filamentous haemagglutinin, pertactin, fimbriae, diphtheria and tetanus were measured by electrochemiluminescence-based multiplex assay.

Results

Overall, 91 PWWH and 136 HIV-uninfected pregnant women were enrolled. All PWWH were on

SUBMITTER: Nunes MC 

PROVIDER: S-EPMC10653295 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature