Cish knockout mice exhibit similar outcomes to malaria infection despite altered hematopoietic responses.

ABSTRACT: The Cytokine-inducible Src homology 2 domain-containing (CISH) protein is a negative feedback regulator induced by cytokines that play key roles in immunity and erythropoiesis. Single nucleotide polymorphisms (SNPs) in the human CISH gene have been associated with increased susceptibility to severe malaria disease. To directly assess how CISH might influence outcomes in the BALB/c model of malaria anemia, CISH knockout (Cish^-/-) mice on this background were infected with Plasmodium berghei and their hematopoietic responses, cytokine production and ability to succumb to severe malaria disease evaluated. Despite basal erythrocytic disruption, upon P. berghei infection, the Cish ^-/- mice were better able to maintain peripheral blood cel

SUBMITTER: Lakkavaram AL 

PROVIDER: S-EPMC10653303 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature