Polarization-sensitive optical coherence tomography for renal tumor detection in <i>ex vivo</i> human kidneys.

ABSTRACT: Kidney cancer is a kind of high mortality cancer because of the difficulty in early diagnosis and the high metastatic dissemination in treatments. The surgical resection of tumors is the most effective treatment for renal cancer patients. However, precise assessment of tumor margins is a challenge during surgical resection. The objective of this study is to demonstrate an optical imaging tool in precisely distinguishing kidney tumor borders and identifying tumor zones from normal tissues to assist surgeons in accurately resecting tumors from kidneys during the surgery. 30 samples from six human kidneys were imaged using polarization-sensitive optical coherence tomography (PS-OCT). Cross-sectional, enface, and spatial information of kidney samples were obtained for microenvironment r

SUBMITTER: Yan F 

PROVIDER: S-EPMC10653339 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature