Noninvasive diagnosis of significant liver inflammation in patients with chronic hepatitis B in the indeterminate phase.

ABSTRACT: The presence of significant liver inflammation is an important indication for antiviral treatment in patients with chronic hepatitis B (CHB) in the indeterminate phase. We aimed to establish a non-invasive nomogram to predict significant liver inflammation in these patients. A total of 195 CHB patients in the indeterminate phase were randomly split into training and validation sets. The least absolute shrinkage and selection operator and logistic regression were applied to identify risk factors and establish a predictive model. A calibration curve, decision curve analysis (DCA), and receiver operating characteristic (ROC) curve were applied to assess the performance of the nomogram. The median age was 42.0 y and 59.5% of the patients were male. Alkaline phosphatase, γ-glutamyl transpeptida

SUBMITTER: Zhan J 

PROVIDER: S-EPMC10653690 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature