Mechanisms of resveratrol against diabetic wound by network pharmacology and experimental validation.

ABSTRACT:

Background

Resveratrol (RSV) that possesses anti-oxidative, anti-inflammatory, and pro-angiogenic effects is an effective drug for diabetic wound (DW), while its pharmacological mechanism remains to be elucidated. In this study, we apply network pharmacology and experimental validation approach to reveal the potential mechanism of RSV against DW.

Methods

We obtained potential targets for RSV and DW from the publicly available database. Using interaction networks and conducting GO and KEGG pathway enrichment analyses, we constructed target-pathway networks to explore the relationship between RSV and DW. To validate the pharmacological mechanism of RSV, we induced the DW model.

Results

Ninety overlapped targets between RSV and DW were obtained, and the hub genes of the

SUBMITTER: Youjun D 

PROVIDER: S-EPMC10653769 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature