AP2XII-1 is a negative regulator of merogony and presexual commitment in <i>Toxoplasma gondii</i>.

ABSTRACT:

Importance

Sexual development is vital for the transmission, genetic hybridization, and population evolution of apicomplexan pathogens, which include several clinically relevant parasites, such as Plasmodium, Eimeria, and Toxoplasma gondii. Previous studies have demonstrated different morphological characteristics and division patterns between asexual and sexual stages of the parasites. However, the primary regulation is poorly understood. A transition from the asexual to the sexual stage is supposedly triggered/accompanied by rewiring of gene expression and controlled by transcription factors and chromatin modulators. Herein, we discovered a tachyzoite-specific transcriptional factor AP2XII-1, which represses the presexual development in the asexual tachyzoite stage

SUBMITTER: Fan F 

PROVIDER: S-EPMC10653792 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature