Inbred SJL mice recapitulate human resistance to Cryptococcus infection due to differential immune activation.

ABSTRACT: Cryptococcosis remains a significant threat to human health. While the popular C57BL/6J mouse model of cryptococcosis has some advantages, there are some serious shortcomings that limit the ability of researchers to address the disease. Since humans are resistant to environmental cryptococcal infection until rendered immunodeficient while C57BL/6J mice are innately susceptible, we screened 15 inbred mouse strains for resistance to Cryptococcus infection. The SJL/J mouse strain was unusually resistant to several virulent strains of Cryptococcus while the closely related FVB/J strain was susceptible. The infection pathobiology in SJL/J mice and susceptible mice was similar for the first 7-10 days then markedly diverged toward pathogen clearance. Interferon-gamma (IFN-γ) express

SUBMITTER: Davis MJ 

PROVIDER: S-EPMC10653822 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature