The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans.

ABSTRACT: Transcription factors (TFs) play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans. We found that activation of the transcription factor C4_02500C_A (Adr1) conferred significant resistance against fluconazole. In Saccharomyces cerevisiae, Adr1 is a carbon-source-responsive zinc-finger transcription factor required for transcription of the glucose-repressed gene ADH1 and of genes required for ethanol, glycerol, and fatty acid utilization. Motif scanning of promoter elements suggests that Adr1 may be rewired in fungi and govern the ergosterol synthesis pathway in C. albicans. Because previous studies have identified the zinc-cluster transcription factor Upc2 as a regulator of the ergosterol

SUBMITTER: Shrivastava M 

PROVIDER: S-EPMC10653825 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature