Rapid and strain-specific resistance evolution of <i>Staphylococcus aureus</i> against inhibitory molecules secreted by <i>Pseudomonas aeruginosa</i>.

ABSTRACT:

Importance

Polymicrobial infections are common. In chronic infections, the different pathogens may repeatedly interact, which could spur evolutionary dynamics with pathogens adapting to one another. Here, we explore the potential of Staphylococcus aureus to adapt to its competitor Pseudomonas aeruginosa. These two pathogens frequently co-occur, and P. aeruginosa is seen as the dominant species being able to displace S. aureus. We studied three different S. aureus strains and found that all became quickly resistant to inhibitory compounds secreted by P. aeruginosa. Our experimental evolution revealed strains-specific adaptations with three main factors contributing to resistance evolution: (i) overproduction of staphyloxanthin, a molecule pr

SUBMITTER: Niggli S 

PROVIDER: S-EPMC10653847 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature