Candida-induced granulocytic myeloid-derived suppressor cells are protective against polymicrobial sepsis.

ABSTRACT: Polymicrobial intra-abdominal infections (IAI) can lead to life-threatening sepsis with significant morbidity and mortality, especially when pathogenic fungi are involved. We have employed an established clinically relevant mouse model of fungal/bacterial IAI and shown that immunization with low-virulence Candida species, that is, Candida dubliniensis, can induce responses that protect against sepsis via the suppression of lethal inflammation. This protection is dependent on long-lived Gr-1⁺ polymorphonuclear leukocytes that display characteristics consistent with myeloid-derived suppressor cells (MDSCs) and trained innate immunity. Here we aimed to functionally and phenotypically characterize these protective Gr-1⁺ leukocytes. Compared to nonimmunized c

SUBMITTER: Esher Righi S 

PROVIDER: S-EPMC10653853 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature