New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex.

ABSTRACT:

Importance

All enveloped viruses enter cells by fusing their envelope with a target cell membrane while avoiding premature fusion with membranes of the producer cell-the latter being particularly important for viruses that bud at internal membranes. Flaviviruses bud in the endoplasmic reticulum, are transported through the TGN to reach the external milieu, and enter other cells via receptor-mediated endocytosis. The trigger for membrane fusion is the acidic environment of early endosomes, which has a similar pH to the TGN of the producer cell. The viral particles therefore become activated to react to mildly acidic pH only after their release into the neutral pH extracellular environment. Our study shows that for yellow fever virus (YFV), the mechanism of activation involves active

SUBMITTER: Crampon E 

PROVIDER: S-EPMC10653854 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature