The VBNC state: a fundamental survival strategy of Acinetobacter baumannii.
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ABSTRACT: Importance
Currently, the viable but non-culturable (VBNC) state is an underappreciated niche for pathogenic bacteria which provides a continuous source for recurrent infections and transmission. We propose the VBNC state to be a global persistence mechanism used by various A. baumannii strains to cope with many stresses it is confronted with in the clinical environment and in the host. This requires a novel strategy to detect viable cells of this pathogen that is not only based on plating assays.
SUBMITTER: Konig P
PROVIDER: S-EPMC10653857 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
The VBNC state: a fundamental survival strategy of <i>Acinetobacter baumannii</i>.
König Patricia P Wilhelm Alexander A Schaudinn Christoph C Poehlein Anja A Daniel Rolf R Widera Marek M Averhoff Beate B Müller Volker V
mBio 20230928 5
<h4>Importance</h4>Currently, the viable but non-culturable (VBNC) state is an underappreciated niche for pathogenic bacteria which provides a continuous source for recurrent infections and transmission. We propose the VBNC state to be a global persistence mechanism used by various <i>A. baumannii</i> strains to cope with many stresses it is confronted with in the clinical environment and in the host. This requires a novel strategy to detect viable cells of this pathogen that is not only based o ...[more]
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