Biased eviction of variant histone H3 nucleosomes triggers biofilm growth in <i>Candida albicans</i>.

ABSTRACT:

Importance

Candida albicans lives as a commensal in most healthy humans but can cause superficial skin infections to life-threatening systemic infections. C. albicans also forms biofilms on biotic and abiotic surfaces. Biofilm cells are difficult to treat and highly resistant to antifungals. A specific set of genes is differentially regulated in biofilm cells as compared to free-floating planktonic cells of C. albicans. In this study, we addressed how a variant histone H3V^CTG, a previously identified negative regulator of biofilm formation, modulates gene expression changes. By providing compelling evidence, we show that biased eviction of H3V^CTG nucleosomes at the promoters of biofilm-relevant genes facilitates the accessibility of both t

SUBMITTER: Brahma P 

PROVIDER: S-EPMC10653867 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature