The morphogenic protein CopD controls the spatio-temporal dynamics of PBP1a and PBP2b in <i>Streptococcus pneumoniae</i>.

ABSTRACT:

Importance

Penicillin-binding proteins (PBPs) are essential for proper bacterial cell division and morphogenesis. The genome of Streptococcus pneumoniae encodes for two class B PBPs (PBP2x and 2b), which are required for the assembly of the peptidoglycan framework and three class A PBPs (PBP1a, 1b and 2a), which remodel the peptidoglycan mesh during cell division. Therefore, their activities should be finely regulated in space and time to generate the pneumococcal ovoid cell shape. To date, two proteins, CozE and MacP, are known to regulate the function of PBP1a and PBP2a, respectively. In this study, we describe a novel regulator (CopD) that acts on both PBP1a and PBP2b. These findings provide valuable information for understanding bacterial cell division. Furthermore, know

SUBMITTER: Lenoir C 

PROVIDER: S-EPMC10653890 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature