Targeted curation of the gut microbial gene content modulating human cardiovascular disease.

ABSTRACT:

Importance

One of the most-cited examples of the gut microbiome modulating human disease is the microbial metabolism of quaternary amines from protein-rich foods. By-products of this microbial processing promote atherosclerotic heart disease, a leading cause of human mortality globally. Our research addresses current knowledge gaps in our understanding of this microbial metabolism by holistically inventorying the microorganisms and expressed genes catalyzing critical atherosclerosis-promoting and -ameliorating reactions in the human gut. This led to the creation of an open-access resource, the Methylated Amine Gene Inventory of Catabolism database, the first systematic inventory of gut methylated amine metabolism. More importantly, using this resource we deliver here, we show for t

SUBMITTER: Borton MA 

PROVIDER: S-EPMC10653893 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature