Steamed broccoli sprouts alleviate DSS-induced inflammation and retain gut microbial biogeography in mice.

ABSTRACT:

Importance

Evaluating bacterial communities across different locations in the gut provides a greater insight than fecal samples alone and provides an additional metric by which to evaluate beneficial host-microbe interactions. Here, we show that 10% steamed broccoli sprouts in the diet protects mice from the negative effects of dextran sodium sulfate-induced colitis, that colitis erases biogeographic patterns of bacterial communities in the gut, and that the cecum is not likely to be a significant contributor to colonic bacteria of interest in the DSS mouse model of ulcerative colitis. Mice fed the broccoli sprout diet during colitis performed better than mice fed the control diet while receiving DSS. The identification of accessible dietary components and concentrations that help

SUBMITTER: Holman JM 

PROVIDER: S-EPMC10654075 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature