Proteome efficiency of metabolic pathways in Escherichia coli increases along the nutrient flow.

ABSTRACT: Understanding the allocation of the cellular proteome to different cellular processes is central to unraveling the organizing principles of bacterial physiology. Proteome allocation to protein translation itself is maximally efficient, i.e., it represents the minimal allocation of dry mass able to sustain the observed protein production rate. In contrast, recent studies on bacteria have demonstrated that the concentrations of many proteins exceed the minimal level required to support the observed growth rate, indicating some heterogeneity across pathways in their proteome efficiency. Here, we systematically analyze the proteome efficiency of metabolic pathways, which together account for more than half of the Escherichia coli proteome during exponential growth. Comparing the predict

SUBMITTER: Hu XP 

PROVIDER: S-EPMC10654084 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature