Dataset Information
The heterogenous and diverse population of prophages in Mycobacterium genomes.
Ontology highlight
ABSTRACT: Importance
Mycobacterium species include several human pathogens and mycobacteriophages show potential for therapeutic use to control Mycobacterium infections. However, phage infection profiles vary greatly among Mycobacterium abscessus clinical isolates and phage therapies must be personalized for individual patients. Mycobacterium phage susceptibility is likely determined primarily by accessory parts of bacterial genomes, and we have identified the prophage and phage-related genomic regions across sequenced Mycobacterium strains. The prophages are numerous and diverse, especially in M. abscessus genomes, and provide a potentially rich reservoir of new viruses that can be propagated lytically and used to expand the repertoire of therapeutically useful phages.
SUBMITTER: Abad L
PROVIDER: S-EPMC10654092 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
The heterogenous and diverse population of prophages in <i>Mycobacterium</i> genomes.
mSystems 20231004 5
<h4>Importance</h4><i>Mycobacterium</i> species include several human pathogens and mycobacteriophages show potential for therapeutic use to control <i>Mycobacterium</i> infections. However, phage infection profiles vary greatly among <i>Mycobacterium abscessus</i> clinical isolates and phage therapies must be personalized for individual patients. <i>Mycobacterium</i> phage susceptibility is likely determined primarily by accessory parts of bacterial genomes, and we have identified the prophage ...[more]
