Clinical Evaluation of a Quantitative Imaging Biomarker Supporting Radiological Assessment of Hippocampal Sclerosis.

ABSTRACT:

Objective

To evaluate the influence of quantitative reports (QReports) on the radiological assessment of hippocampal sclerosis (HS) from MRI of patients with epilepsy in a setting mimicking clinical reality.

Methods

The study included 40 patients with epilepsy, among them 20 with structural abnormalities in the mesial temporal lobe (13 with HS). Six raters blinded to the diagnosis assessed the 3T MRI in two rounds, first using MRI only and later with both MRI and the QReport. Results were evaluated using inter-rater agreement (Fleiss' kappa [Formula: see text]) and comparison with a consensus of two radiological experts derived from clinical and imaging data, including 7T MRI.

Results

For the primary outcome, diagnosis of HS, the mean accuracy of the raters improved f

SUBMITTER: Rebsamen M 

PROVIDER: S-EPMC10654177 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature