Association between polymorphisms of immune response genes and early childhood caries - systematic review, gene-based, gene cluster, and meta-analysis.

ABSTRACT:

Background

Early childhood caries is a significant public health concern affecting about 600 million children globally. The etiology of early childhood caries can be explained as an interplay between genetic and environmental factors. Single nucleotide polymorphisms are the most common variations in the human genome. Genetic variations of immune response genes can modify the defense response of the host, and alter the susceptibility to bacterial colonization of the oral cavity and early childhood caries. The aim of this systematic review is to identify genetic variants of immune response genes associated with early childhood caries.

Results

A total of 7124 articles were identified by conducting an elaborate search across various electronic databases and genome-wide associati

SUBMITTER: Aruna P 

PROVIDER: S-EPMC10654314 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature