Prognostic significance of extramedullary disease (EMD) detected on pre-transplant ¹⁸F-FDG PET/CT in patients with multiple myeloma: Results of PIPET-M trial.

ABSTRACT:

Background

It is difficult to prognosticate the post-Autologous Stem Cell Transplant (ASCT) responses in multiple myeloma (MM) with the currently available prognostication models. ¹⁸F-FDGPET/CT has numerous advantages to prognosticate the post-transplant responses by assessing extramedullary disease (EMD) in addition to the extent of active disease. We aimed at identifying the prognostic value of EMD in predicting progression-free survival (PFS) and overall survival (OS).

Methods

This is a single centre prospective study from western India during a study period of 2014-2022 (with a median follow-up of patients of 6 years). All ASCT patients underwent ¹⁸F-FDG-PET/CT as part of pre-transplant workup. The conditioning and treatment protocols were not modif

SUBMITTER: Yanamandra U 

PROVIDER: S-EPMC10654356 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature