Circulating extracellular vesicles in healthy and pathological pregnancies: A scoping review of methodology, rigour and results.

ABSTRACT: Extracellular vesicles (EVs) play a crucial role in pregnancy, revealed by the presence of placental-derived EVs in maternal blood, their in vitro functionality, and their altered cargo in pregnancy pathologies. These EVs are thought to be involved in the development of pregnancy pathologies, such as pre-eclampsia, pre-term birth, and fetal growth restriction, and have been suggested as a source of biomarkers for gestational diseases. However, to accurately interpret their function and biomarker potential, it is necessary to critically evaluate the EV isolation and characterization methodologies used in pregnant cohorts. In this systematic scoping review, we collated the results from 152 studies that have investigated EVs in the blood of pregnant women, and provide a detailed analysis of t

SUBMITTER: Barnes MVC 

PROVIDER: S-EPMC10654380 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature