Biomarkers of lung cancer for screening and in never-smokers-a narrative review.

ABSTRACT:

Background and objective

Lung cancer is the leading cause of cancer-related mortality worldwide, partially attributed to late-stage diagnoses. In order to mitigate this, lung cancer screening (LCS) of high-risk patients is performed using low dose computed tomography (CT) scans, however this method is burdened by high false-positive rates and radiation exposure for patients. Further, screening programs focus on individuals with heavy smoking histories, and as such, never-smokers who may otherwise be at risk of lung cancer are often overlooked. To resolve these limitations, biomarkers have been posited as potential supplements or replacements to low-dose CT, and as such, a large body of research in this area has been produced. However, comparatively little information exists on thei

SUBMITTER: Stephens EKH 

PROVIDER: S-EPMC10654441 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature