Predicting amyloid PET positivity using plasma p-tau181 and other blood-based biomarkers.

ABSTRACT:

Introduction

This study aimed to determine the efficacy of combining plasma phosphorylated tau (p-tau)181, amyloid beta (Aβ)42/Aβ40, neurofilament light (NfL), and apolipoprotein E (APOE) genotypes for detecting positive amyloid positron emission tomography (PET), which is little known in the Asian population, in two independent cohorts.

Methods

Biomarkers were measured using a single-molecule array (Simoa) in a cohort study (Asan). All participants underwent amyloid PET. Significant changes in the area under the curve (AUC) and Akaike Information Criterion values were considered to determine the best model. The generalizability of this model was tested using another cohort (KBASE-V).

Results

In the Asan cohort, after adjusting for age and sex, p-tau181 (AUC = 

SUBMITTER: Kwon HS 

PROVIDER: S-EPMC10654468 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature