Abnormal brain structure in atopic dermatitis: Evidence from Mendelian randomization study.

ABSTRACT:

Background

Structural abnormalities in the brain of patients with atopic dermatitis (AD) have been reported; however, the cause has not been determined yet. Herein, we used Mendelian randomization (MR) to reveal the causal effect of AD on brain structure.

Methods

This study utilized summary statistics from genome-wide association studies (GWASs) to investigate a collection of cerebral structural measures, encompassing cortical thickness (CT), cortical surface area (CA), and subcortical volumes in T1 images. A comprehensive GWAS meta-analysis identified a total of 20 independent single nucleotide polymorphisms linked to AD, surpassing the genome-wide significance threshold (p < 5 × 10⁻⁸). MR estimates were aggregated through the application of the inverse variance weighted me

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10654478 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature