Unveiling the novel immune and molecular signatures of ovarian cancer: insights and innovations from single-cell sequencing.

ABSTRACT: Ovarian cancer is a highly heterogeneous and lethal malignancy with limited treatment options. Over the past decade, single-cell sequencing has emerged as an advanced biological technology capable of decoding the landscape of ovarian cancer at the single-cell resolution. It operates at the level of genes, transcriptomes, proteins, epigenomes, and metabolisms, providing detailed information that is distinct from bulk sequencing methods, which only offer average data for specific lesions. Single-cell sequencing technology provides detailed insights into the immune and molecular mechanisms underlying tumor occurrence, development, drug resistance, and immune escape. These insights can guide the development of innovative diagnostic markers, therapeutic strategies, and prognostic indicators. Ov

SUBMITTER: Li Z 

PROVIDER: S-EPMC10654630 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature