NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK.

ABSTRACT: Among follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display poor prognosis. NF-κB signaling pathways are involved in tumor progression of various cancers. Here, we finely characterize the NF-κB pathways and their involvement in TC. By using immunoblot and gel shift assays, we demonstrated that both classical and alternative NF-κB pathways are activated in ten TC-derived cell lines, leading to activated RelA/p50 and RelB/p50 NF-κB dimers. By analyzing the RNAseq data of the large papillary thyroid carcinoma (PTC) cohort from The Cancer Genome Atlas (TCGA) project, we identified a tumor progression-related NF-κB signature in BRAF^V600E mutated-PTCs. That corroborated with the role of RelA and RelB in cell migration and

SUBMITTER: Cormier F 

PROVIDER: S-EPMC10654696 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature