Anticancer activity, phytochemical investigation and molecular docking insights of Citrullus colocynthis (L.) fruits.

ABSTRACT: Cancer disease is regarded as one of the most significant public health issues, regardless of economic standards. Medicinal plants are now regarded as a natural source of anticancer medicines due to their antioxidant and anti-mutagenic actions. Cucurbitaceae is considered to be one of the most economically significant families. One family species is Citrullus colocynthis (L.), which has a high concentration of many active secondary chemical metabolites. Various C. colocynthis plant extracts showed cytotoxicity against some cancer cells. This study aims to identify the C. colocynthis fruit components and determine whether they have anticancer action against MIA PaCa-2 and A431 cells. High-Performance Liquid Chromatography/Quadrupole Time of Flight/Mass Spectrometry (HPLC/QTOF/MS); the techn

SUBMITTER: Mandour YM 

PROVIDER: S-EPMC10654702 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature