A National Retrospective Study of Antidepressants' Effects on Overdose and Self-Harm Among Adults Treated With Opioid Analgesics.

ABSTRACT:

Objective

Because individuals with a history of depression who are receiving opioids are at higher risk for adverse events, the authors examined whether antidepressant treatment reduces risk for overdose and self-harm among individuals with a history of depression who receive opioids.

Methods

Commercial insurance claims of individuals with a history of depression receiving opioids from 2007 to 2017 were used to quantify the association between antidepressant fills and adverse events among individuals after initiation of opioid treatment; the authors accounted for selection into treatment and used discrete-time, proportional hazards survival models.

Results

Among 283,374 adults with a history of depression treatment, 8,203 experienced 47,486 adverse events from 2007 to

SUBMITTER: Sherry TB 

PROVIDER: S-EPMC10654712 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature