Low bone mineral density is associated with gray matter volume decrease in UK Biobank.

ABSTRACT:

Objectives

Previous research has found an association of low bone mineral density (BMD) and regional gray matter (GM) volume loss in Alzheimer's disease (AD). We were interested whether BMD is associated with GM volume decrease in brains of a healthy elderly population from the UK Biobank.

Materials and methods

T1-weighted images from 5,518 women (M_Age = 70.20, SD = 3.54; age range: 65-82 years) and 7,595 men (M_Age = 70.84, SD = 3.68; age range: 65-82 years) without neurological or psychiatric impairments were included in voxel-based morphometry (VBM) analysis in CAT12 with threshold-free-cluster-enhancement (TFCE) across the whole brain.

Results

We found a significant decrease of GM volume in women in the superior frontal gyri, mid

SUBMITTER: Kalc P 

PROVIDER: S-EPMC10654785 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature