Cost-Effectiveness of Liquid Biopsy for Colorectal Cancer Screening in Patients Who Are Unscreened.

ABSTRACT:

Importance

Despite recommendations for universal screening, adherence to colorectal cancer screening in the US is approximately 60%. Liquid biopsy tests are in development for cancer early detection, but it is unclear whether they are cost-effective for colorectal cancer screening.

Objective

To estimate the cost-effectiveness of liquid biopsy for colorectal cancer screening in the US.

Design, setting, and participants

In this economic evaluation, a Markov model was developed to compare no screening and 5 colorectal cancer screening strategies: colonoscopy, liquid biopsy, liquid biopsy following nonadherence to colonoscopy, stool DNA, and fecal immunochemical test. Adherence to first-line screening with colonoscopy, stool DNA, or fecal immunochemical test was assumed t

SUBMITTER: Aziz Z 

PROVIDER: S-EPMC10654798 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature