Prevalence, risk factors, and outcomes associated with delayed second doses of antibiotics in sepsis at a large academic medical center.

ABSTRACT:

Objective

To evaluate the prevalence, risk factors, and clinical impact of delays in second doses of antibiotics in patients with sepsis.

Design

Single-center, retrospective, observational study.

Setting

Large teaching hospital.

Patients

Adult patients who triggered an electronic sepsis alert in the emergency department (ED), received ≥2 doses of vancomycin or an antipseudomonal beta-lactam, and were discharged with an ICD-10 sepsis code.

Methods

We assessed the prevalence of delays in second doses of antibiotics by ≥25% of the recommended dose interval and conducted multivariate regression analyses to assess for risk factors for delays and in-hospital mortality.

Results

The cohort included 449 patients, of whom 123 (27.4%) had delays in second do

SUBMITTER: Cook ME 

PROVIDER: S-EPMC10654957 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature