BMP2 gene transfer induces pericardial effusion and inflammatory response in the ischemic porcine myocardium.

ABSTRACT: Pro-angiogenic gene therapy is being developed to treat coronary artery disease (CAD). We recently showed that bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factor-A synergistically regulate endothelial cell sprouting in vitro. BMP2 was also shown to induce endocardial angiogenesis in neonatal mice post-myocardial infarction. In this study, we investigated the potential of BMP2 gene transfer to improve cardiomyocyte function and neovessel formation in a pig chronic myocardial infarction model. Ischemia was induced in domestic pigs by placing a bottleneck stent in the proximal part of the left anterior descending artery 14 days before gene transfer. Intramyocardial gene transfers with adenovirus vectors (1 × 10¹² viral particles/pig) containing either

SUBMITTER: Pulkkinen HH 

PROVIDER: S-EPMC10655027 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature