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Rationale and design of a randomized trial of the dapagliflozin evaluation on atrial fibrillation patients followed Cox-Maze IV: the DETAIL-CMIV study.


ABSTRACT:

Background and aims

Dapagliflozin has been widely used for the treatment of type 2 diabetes mellitus (T2DM) and heart failure (HF). However, data concerning the association between dapagliflozin and the recurrence of atrial fibrillation (AF), especially in patients following Cox Maze IV (CMIV), are rare. We aim to explore the effect of dapagliflozin on the recurrence of AF after CMIV with and without T2DM or HF.

Methods

The study of dapagliflozin evaluation in atrial fibrillation patients followed by Cox-Maze IV (DETAIL-CMIV) is a prospective, double-blind, randomized, placebo-controlled trial. A total of 240 AF patients who have received the CMIV procedure will be randomized into the dapagliflozin group (10 mg/day, n=120) and the placebo group (10 mg/day, n=120) and treated for 3 months. The primary endpoint is any documented atrial tachyarrhythmia (AF, atrial flutter or atrial tachycardia [AF/AT]) lasting 30 s following a blanking period of 3 months after CMIV.

Conclusion

DETAIL-CMIV will determine whether the SGLT2 inhibitor dapagliflozin, added to guideline-recommended postoperative AF therapies, safely reduces the recurrence rate of AF in patients with and without T2DM or HF.

Clinical trial registration

NCT05816733.

SUBMITTER: Peng Z 

PROVIDER: S-EPMC10655060 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Rationale and design of a randomized trial of the dapagliflozin evaluation on atrial fibrillation patients followed Cox-Maze IV: the DETAIL-CMIV study.

Peng Zhan Z   Osmanaj Florian F   Yang Yunxiao Y   Hua Kun K   Yang Xiubin X  

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20231101 11


<h4>Aims</h4>Dapagliflozin has been widely used for the treatment of type 2 diabetes mellitus (T2DM) and heart failure (HF). However, data concerning the association between dapagliflozin and the recurrence of atrial fibrillation (AF), especially in patients following Cox-Maze IV (CMIV), are rare. We aim to explore the effect of dapagliflozin on the recurrence of AF after CMIV with and without T2DM or HF.<h4>Methods and results</h4>The study of dapagliflozin evaluation in AF patients followed by  ...[more]

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