Metabolic bulk volume from FDG PET as an independent predictor of progression-free survival in follicular lymphoma.

ABSTRACT:

Background

Total metabolic tumor volume (TMTV) in ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) predicts patient outcome in follicular lymphoma (FL); however, it requires laborious segmentation of all lesions. We investigated the prognostic value of the metabolic bulk volume (MBV) obtained from the single largest lesion.

Methods

Pretreatment FDG PET/computed tomography (CT) scans of 201 patients were analyzed for TMTV and MBV using a 41% maximum standardized uptake value (SUVmax) threshold.

Results

During a median follow-up of 3.2 years, 54 events, including 14 deaths, occurred. Optimal cut-offs were 121.1 cm³ for TMTV and 24.8 cm³ for MBV. Univariable predictors of progression-free survival (PFS) included a high Foll

SUBMITTER: So H 

PROVIDER: S-EPMC10655116 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature