Cognitive impairment in Chinese adult patients with type III spinal muscular atrophy without disease-modifying treatment.

ABSTRACT:

Objective

Spinal muscular atrophy (SMA) is a neurodegenerative disorder characterized by the degeneration of motor neurons in the spinal cord. It remains uncertain whether the cognitive performance of adult patients with SMA is impaired. The objective of this study was to assess the cognitive profile of adult Chinese patients with SMA and the association between clinical features and cognitive ability, particularly executive function.

Methods

This cross-sectional study included 22 untreated adult patients with type III SMA and 20 healthy subjects. The following variables were assessed: general intelligence, memory, attention, language, executive function, depression, anxiety, and other demographic and clinical parameters. In addition, physical function was evaluated using th

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10655145 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature