Characterization of genomic instability-related genes predicts survival and therapeutic response in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and is the leading cause of cancer death worldwide. Its progression is characterized by genomic instability. In turn, the level of genomic instability affects the prognosis and immune status of patients with LUAD. However, the impact of molecular features associated with genomic instability on the tumor microenvironment (TME) has not been well characterized. In addition, the effect of the genes related to genomic instability in LUAD on individualized treatment of LUAD is unknown.

Methods

The RNA-Sequencing, somatic mutation, and clinical data of LUAD patients were downloaded from publicly available databases. A genetic signature associated with genomic instability (GSAGI) w

SUBMITTER: Li S 

PROVIDER: S-EPMC10655275 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature