Mismatch of populations between randomised controlled trials of perioperative interventions in major abdominal surgery and current clinical practice.

ABSTRACT:

Background

Demographics of patients undergoing major abdominal surgery are changing. External validity of relevant RCTs may be limited by participants not resembling patients encountered in clinical practice. We aimed to characterise differences in age, weight, BMI, and ASA grade between participants in perioperative trials in major abdominal surgery and patients in a reference real-world clinical practice sample. The secondary aim was to investigate whether time since trial publication was associated with increasing mismatch between these groups.

Methods

MEDLINE and Embase were searched for multicentre RCTs from inception to September 2022. Studies of perioperative interventions in adults were included. Studies that limited enrolment based on age, weight, BMI, or ASA status

SUBMITTER: Ridgeon E 

PROVIDER: S-EPMC10655289 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature