Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia.

ABSTRACT:

Background

Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease pathology. However, the mechanism of beneficial effects of exercise on the brain remains to be further explored. In this study, we investigated the effect of an exercise-induced metabolite, lactate, on the microglia phenotype and its association with learning and memory.

Results

Microglia were hyperactivated in the brains of AlCl₃/D-gal-treated mice, which was associated with cognitive decline. Running exercise ameliorated the hyperactivation and increased the anti-inflammatory/reparative phenotype of microglia and improved cognition. Mice were injected intraperitoneally with sodium lactate (NaLA) had similar beneficial effects as t

SUBMITTER: Han H 

PROVIDER: S-EPMC10655345 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature