Correlation of gut microbiota with leukopenia after chemotherapy in patients with colorectal cancer.

ABSTRACT:

Background

The most common toxic side effect after chemotherapy, one of the main treatments for colorectal cancer (CRC), is myelosuppression.

Objective

To analyze the correlation between gut microbiota and leukopenia after chemotherapy in CRC patients.

Methods

Stool samples were collected from 56 healthy individuals and 55 CRC patients. According to the leukocytes levels in peripheral blood, the CRC patients were divided into hypoleukocytes group (n = 13) and normal leukocytes group (n = 42). Shannon index, Simpson index, Ace index, Chao index and Coverage index were used to analyze the diversity of gut microbiota. LDA and Student's t-test(St test) were used for analysis of differences. Six machine learning algorithms, including logistic regression (LR) algorithm, ran

SUBMITTER: Xiaofeng N 

PROVIDER: S-EPMC10655349 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature