Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology.

ABSTRACT: While the field of precision oncology is rapidly expanding and more targeted options are revolutionizing cancer treatment paradigms, therapeutic resistance particularly to immunotherapy remains a pressing challenge. This can be largely attributed to the dynamic tumor-stroma interactions that continuously alter the microenvironment. While to date most advancements have been made through examining the clinical utility of tissue-based biomarkers, their invasive nature and lack of a holistic representation of the evolving disease in a real-time manner could result in suboptimal treatment decisions. Thus, using minimally-invasive approaches to identify biomarkers that predict and monitor treatment response as well as alert to the emergence of recurrences is of a critical need. Currently, resear

SUBMITTER: Asleh K 

PROVIDER: S-EPMC10655470 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature