Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation.

ABSTRACT: Atopic dermatitis (AD) is a common skin disease involving important immune mechanisms. There is an unmet need for a treatment for this condition. Herein, we focused on elucidating the role of Bi_2-xMn_xO₃ nanospheres (BM) in alleviating skin inflammation in AD-like C57BL/6 mice. The BM was fabricated via sacrificial templates and its biosafety was systematically evaluated. The BM was applied topically to skin lesions of AD-like C57BL/6 mice. The phenotypic and histological changes in the skin were examined carefully. The responses of barrier proteins, inflammatory cytokines and cells to BM were evaluated in HaCaT cells and AD mouse models. The data demonstrated that BM treatment alleviated the AD phenotypes and decreased the level of inflammatory factors, whi

SUBMITTER: Li M 

PROVIDER: S-EPMC10655471 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature