Fe-doped carbon dots: a novel biocompatible nanoplatform for multi-level cancer therapy.

ABSTRACT:

Background

Tumor treatment still remains a clinical challenge, requiring the development of biocompatible and efficient anti-tumor nanodrugs. Carbon dots (CDs) has become promising nanomedicines for cancer therapy due to its low cytotoxicity and easy customization.

Results

Herein, we introduced a novel type of "green" nanodrug for multi-level cancer therapy utilizing Fe-doped carbon dots (Fe-CDs) derived from iron nutrient supplement. With no requirement for target moieties or external stimuli, the sole intravenous administration of Fe-CDs demonstrated unexpected anti-tumor activity, completely suppressing tumor growth in mice. Continuous administration of Fe-CDs for several weeks showed no toxic effects in vivo, highlighting its exceptional biocompatibility. The as-synthesi

SUBMITTER: Yang M 

PROVIDER: S-EPMC10655501 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature