Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering.

ABSTRACT: Ongoing cell therapy trials have demonstrated the need for precision control of donor cell behavior within the recipient tissue. We present a methodology to guide stem cell-derived and endogenously regenerated neurons by engineering the microenvironment. Being an "approachable part of the brain," the eye provides a unique opportunity to study neuron fate and function within the central nervous system. Here, we focused on retinal ganglion cells (RGCs)-the neurons in the retina are irreversibly lost in glaucoma and other optic neuropathies but can potentially be replaced through transplantation or reprogramming. One of the significant barriers to successful RGC integration into the existing mature retinal circuitry is cell migration toward their natural position in the retina. Our in silico

SUBMITTER: Soucy JR 

PROVIDER: S-EPMC10655587 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature