Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation.

ABSTRACT: Huntington disease (HD) is a neurodegenerative disease associated with polyglutamine expansion in the protein huntingtin (HTT). Although the length of the polyglutamine repeat correlates with age at disease onset and severity, psychological, cognitive and behavioral complications point to the existence of disease modifiers. Mitochondrial dysfunction and metabolic deregulation are both associated with the HD but, despite multi-omics characterization of patients and model systems, their mechanisms have remained elusive. Systems analysis of multi-omics data and its validation by using a yeast model could help to elucidate pathways that modulate protein aggregation. Metabolomics analysis of HD patients and of a yeast model of HD was, therefore, carried out. Our analysis showed a considerable o

SUBMITTER: Pradhan SS 

PROVIDER: S-EPMC10655815 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature