Network-specific metabolic and haemodynamic effects elicited by non-invasive brain stimulation.

ABSTRACT: Repetitive transcranial magnetic stimulation (TMS), when applied to the dorsolateral prefrontal cortex (dlPFC), treats depression. Therapeutic effects are hypothesized to arise from propagation of local dlPFC stimulation effects across distributed networks; however, the mechanisms of this remain unresolved. dlPFC contains representations of different networks. As such, dlPFC TMS may exert different effects depending on the network being stimulated. Here, to test this, we applied high-frequency TMS to two nearby dlPFC targets functionally embedded in distinct anti-correlated networks-the default and salience networks- in the same individuals in separate sessions. Local and distributed TMS effects were measured with combined ¹⁸fluorodeoxyglucose positron emission tomography and fu

SUBMITTER: Eldaief MC 

PROVIDER: S-EPMC10655825 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature